28 results for “opioid-induced respiratory depression”
78y · Male·Cerebral infarction and hypoxic brain damage due to the combined effects of isch…
… observations despite new sedating medications. Combination morphine with quetiapine likely exacerbated respiratory depression. The patient rapidly deteriorated with hypoxia, hypotension, and altered consciousness. Whil…
Hypoxic-ischaemic encephalopathy following ventilatory failure/cardiac arrest (R…
Two obese patients died from hypoxic-ischaemic encephalopathy following cardio-respiratory deterioration post-operatively at a private hospital without overnight medical cover. John Ryan (54) de…
53y · Male·fentanyl and oxycodone toxicity
… clinical information; failure to recognise clinical deterioration despite clear family observations of respiratory depression and profound drowsiness; and prescription of slow-release oxycodone (OxyContin) in combinati…
57y · Male·Aspiration pneumonia in an HIV positive man on methadone
…istent with therapeutic use. Key clinical lessons: patients on methadone require careful monitoring for respiratory depression and loss of airway protective reflexes; combined sedating medications increase aspiration ri…
5y · Female·Hypoxic-ischaemic Encephalopathy due to methadone toxicity
…father did not check on LA for extended periods despite hot weather and her recent minor illness; once opioid-induced respiratory depression and hypoxia developed, naloxone proved ineffective as significant brain damage …
79y · Male·hypoxic brain injury due to cardio-respiratory arrest caused by opioid toxicity
…documentation or monitoring. Wang showed clinical somnolence from 5pm that day—an early warning sign of respiratory depression. The expert consensus was these morphine doses were inappropriate given Wang's age (79), opi…
16y · Female·Respiratory arrest due to the depressant effect of opiate medication
…ed skull fracture from a golf ball strike and was admitted to Royal North Shore Hospital. She died from respiratory arrest due to opioid-induced respiratory depression, which was entirely preventable. Multiple clinical …
34y · Male·Mixed methadone and thioridazine toxicity
…thadone maintenance (110mg daily) for opioid addiction and was prescribed thioridazine 100mg nightly for depression. Post-mortem toxicology showed toxic methadone levels (1.9mg/L) and therapeutic thioridazine despite sta…
54y · Female·Opioid toxicity (predominantly fentanyl)
…ement enhanced monitoring protocols (at least 2-hourly observations) when opioids are started; escalate respiratory depression signs (low oxygen saturation plus vomiting) to senior medical staff; and restrict fentanyl p…
25y · Female·complications of opioid toxicity
Ellie Marlene Hare, 25, died from opioid toxicity after injecting methadone on two consecutive nights with Matthew Drake. She was opioid-naïve, having not used regularly for several years. On the morning of her death, Dr…
47y · Male·Bronchopneumonia on a background of methadone and benzodiazepine use
… He suffered chronic severe asthma and recurrent chest infections. Key clinical issues: (1) Methadone's respiratory depressant effects are contraindicated in severe asthma/respiratory disease per product information and…
57y · Male·Mixed drug toxicity (heroin, methadone, benzodiazepines including novel benzodia…
Raymond John Flaherty, a 57-year-old Wurundjeri man with longstanding opioid and benzodiazepine dependence, died from mixed drug toxicity involving heroin, methadone, prescribed diazepam, unprescribed benzodiazepines inc…
41y · Female·Aspiration pneumonia in the setting of a mixed drug toxicity
…evated tramadol with benzodiazepines (alprazolam, diazepam, temazepam, oxazepam) causing synergistic CNS depression. Evidence suggests Emma consumed significantly more tramadol than prescribed (up to 850mg versus 450-500…
33y · Female·Hypoxic ischaemic encephalopathy complicating mixed drug toxicity
Jessica Higgins, a 33-year-old woman with chronic pain on high-dose opioids, underwent ketamine infusion with planned opioid rotation to methadone in May 2017. She was discharged on 23 May on methadone 5mg twice daily pl…
22y · Male·Combined drug toxicity (alprazolam, methadone, diazepam, dextromethorphan and op…
Adrian Westlund, a 22-year-old with complex drug-seeking behaviour and polypharmacy addiction, died of combined drug toxicity (alprazolam, methadone, diazepam, dextromethorphan). He manipulated multiple GPs by misreprese…
36y · Female·Pneumonia complicating combined drug effect
…ined heroin and, in combination with prescription medications (dexamphetamine and temazepam), developed respiratory depression and aspiration pneumonia. The coroner found she had manipulated multiple systems—Department …
5y · Male·Combined effects of prescribed morphine, valproic acid and midazolam leading to …
… of morphine with the child's existing sedative medications (clobazam, valproic acid, clonidine) led to respiratory depression and death. The death was potentially preventable through: specialist consultation on polypha…
49y · Female·Fatal Cardiac Arrhythmia
…one day after successful abdominal hysterectomy and sling surgery. The coroner found the cause was not opioid-induced respiratory depression despite post-operative narcotic use (tramadol, fentanyl). Critical clinical les…
21y · Male·combined effect of a cocktail of drugs taken by him, which caused central nervou…
Paul Fennessy, 21 years old, died from a cocktail of drugs causing central nervous system and respiratory depression with positional asphyxia on 6 January 2010. He had a decade-long history of polysubstance ab…
51y · Female·Cannot be determined; likely mixed drug (including alcohol) toxicity or undeterm…
Margaret Joy O'Donnell, aged 51, died between 9-15 June 2018. The cause of death could not be determined due to decomposition, but toxicology revealed mixed drug toxicity including fatal levels of methadone and hydromorp…
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