54 results for “opioid tolerance”
44y · Female·Heroin toxicity
…cember, during approved leave, she used heroin intravenously and overdosed. Critical learning: her lowered opioid tolerance from three years of abstinence meant she did not adjust her heroin dose, creating high overdose …
56y · Male·Complications of intravenous drug use
Ross James Davis, aged 56, died from complications of intravenous opioid use. He had severe chronic obstructive pulmonary disease exacerbated by heavy smoking, chronic pain, and o…
22y · Male·Combined drug toxicity (methadone and benzodiazepines)
…nowledge or consent. The coroner identified that takeaway methadone dispensing created unsecured access to opioids, and that recent prison release substantially elevated overdose risk due to loss of opioid tolerance duri…
72y · Female·Combined drug toxicity (tapentadol, fluoxetine)
…ruary 2024, no single clinician took primary responsibility for her care. A GP trainee initiated a complex opioid rotation—a high-risk procedure requiring experienced oversight—without adequate follow-up or monitoring. M…
38y · Male·Toxicity to heroin
…2018. Key clinical lesson: recently released prisoners face markedly elevated overdose risk due to reduced opioid tolerance after enforced abstinence, combined with access to more potent drugs and potential purity variat…
23y · Male·combined drug toxicity (methadone, clozapine, quetiapine, diazepam, chlorpromazi…
…spital doctors; Alma Street ward staff received no specific instructions about methadone toxicity signs; tolerance was lost during abstinence, making him vulnerable to overdose; and nursing staff failed to escalate conc…
42y · Male·methadone toxicity
…der, died from methadone toxicity while in custody at Long Bay Correctional Centre. He was not enrolled in opioid substitution therapy but had diverted methadone in the past. He failed to attend a scheduled Drug and Alco…
45y · Male·methylenedioxymethylamphetamine (MDMA or 'ecstasy') toxicity
…leave from the Salvation Army Bridge Program when he relapsed, obtaining and ingesting MDMA. His reduced tolerance following abstinence may have contributed to fatal overdose. The coroner found the death accidental. Cli…
37y · Male·Cardiomegaly and recent ingestion of methadone
…icity. A long-term user of prescription pain relief medications following prior injuries, he had developed opioid addiction. In December 2009, following a social event, he illicitly obtained methadone without a valid tre…
23y · Male·mixed prescription drug toxicity (tramadol and alprazolam)
…o take it for foot pain. He combined this with alprazolam obtained via prescription before the trip. As an opioid-naive individual, he ingested toxic quantities (5 tramadol and 8 alprazolam capsules). The benzodiazepine-…
44y · Male·Heroin toxicity in the setting of ischaemic heart disease
…ng poor compliance history. Within hours of release, he obtained heroin and used it, likely with reduced tolerance after prison abstinence. Key clinical lessons: (1) recently released prisoners face markedly elevated ov…
34y · Male·Mixed drug toxicity
…e parole supervision. Clinical lessons include: recently released prisoners have markedly decreased drug tolerance after period of abstinence while incarcerated, making them vulnerable to fatal overdose; FDS attended a …
54y · Female·combined drug toxicity (heroin, morphine, cannabis, and prescription medications…
…c effects of heroin combined with her regular prescription medications, likely in the context of reduced tolerance to opioids. Clinicians should remain vigilant for substance relapse in patients with addictive histories…
34y · Female·Mixed drug toxicity (ethanol, methadone, diazepam and risperidone)
…g emergency services. A toxicologist noted that her recent missed methadone doses would have lowered her tolerance, increasing CNS depression risk. Emergency physicians advised the nurse's decision to monitor rather tha…
53y · Female·mixed prescription drug toxicity
…failure to involve addiction medicine and pain management specialists, inadequate consideration of loss of opioid tolerance when reintroducing methadone after a break, and permitting unsupervised self-management of medic…
58y · Female·undetermined; possible mixed drug intoxication and/or adrenal insufficiency
…insufficiency were potential contributors. She had complex medical conditions requiring chronic pethidine (opioid) therapy for gut pain management. Toxicology revealed toxic pethidine levels and additional CNS depressant…
32y · Male·Multiple drug toxicity (including heroin)
Kirk Steven Ardern, a 32-year-old male with a long history of opioid dependence and substance abuse, died from multiple drug toxicity (including heroin) three days after relea…
31y · Male·mixed prescription drug toxicity (methadone, fluvoxamine, tramadol, mirtazapine …
…azapine, diazepam) combined with advanced coronary atherosclerotic disease. He had a documented history of opioid addiction, multiple emergency presentations for medication overdose, and drug-seeking behaviour managed by…
24y · Male·bronchopneumonia complicating oxycodone toxicity
…out checking prescription history or drug addict registers, unaware he was a documented drug addict. His tolerance had decreased due to limited access in June, making him opioid-naïve when he fatally overdosed. Key clin…
44y · Male·Combined drug effect (oxycodone and benzodiazepines)
… then misused the medication intravenously in combination with his regular benzodiazepines. He had reduced opioid tolerance following 21 months without opioid replacement therapy. The prescriptions themselves were not in…
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