101 results for “CNS depression”
63y · Male·Hypoxic ischaemic brain injury and pneumonia complicating cardiac arrest in a ma…
…sychiatric unit. He presented to ED on 15 August 2019 with acute psychosis requiring sedation with multiple CNS-depressing medications (diazepam, olanzapine, droperidol, promethazine, chlorpromazine). Critical failures …
50y · Female·Potentially fatal multiple drug toxicity (oxycodone, mirtazapine, citalopram, cl…
Ms RF, a 50-year-old woman with epilepsy and chronic pain from a workplace wrist injury, died from potentially fatal multiple drug toxicity involving oxycodone, mirtazapine, citalopram, clonazepam, and pregabalin. She en…
72y · Female·Combined drug toxicity (tapentadol, fluoxetine)
Linda Joy Bridle, 72, died from combined drug toxicity (tapentadol and fluoxetine) with a contributing subdural haemorrhage. She had multiple chronic conditions including heart failure and chronic pain, managed through c…
53y · Female·mixed prescription drug toxicity
Deearne Joan Barnes, a 53-year-old woman with complex psychiatric history including depression, OCD, substance abuse disorder, and chronic non-cancer pain, died from mixed prescription drug toxicity …
28y · Female·methadone toxicity
…g) would have been more appropriate. She received concurrent benzodiazepines and antipsychotics, increasing CNS depression risk. Daily supervised dosing occurred at the pharmacy with clinical checks, but no concerns wer…
46y · Female·Multiple severe trauma suffered in a motor vehicle accident
A 46-year-old woman died in a head-on motor vehicle collision after her car drifted across the centre line on the Bass Highway. She had reported feeling tired earlier that morning and had intended to pull over to sleep. …
35y · Male·Hypoxic brain injury complicating cardiac arrest in the setting of combined hero…
…d in November 2018. He had combined heroin, alcohol, and doxylamine (antihistamine), causing respiratory depression and cardiac arrest. Despite 22 minutes of paramedic CPR and hospital admission, he suffered irreversible…
56y · Female·Acute combined drug toxicity
…n side effects may lead to dose escalation; and considering the risks of fall-related deaths in patients on CNS-depressant medications. No evidence supports involvement of a third party or intentional overdose.
43y · Female·Combined drug toxicity (tapentadol, sertraline, gabapentin, periciazine, carbama…
A 43-year-old woman with complex psychiatric history including schizoaffective disorder, borderline personality disorder, and chronic suicidality died from combined drug toxicity involving eight medications (tapentadol, …
24y · Male·Multiple Traumatic Injuries sustained as a result of motor vehicle crash during …
…driver's polypharmacy (cocaine, cannabis, tramadol >2x therapeutic range, benzodiazepam) caused substantial CNS depression and impairment. The coroner made recommendations to amend police policy to mandate lights/sirens…
34y · Female·Global cerebral ischaemia secondary to mixed drug toxicity including a substance…
A 34-year-old woman with a 10-year history of heroin dependence died from mixed drug toxicity including heroin after injecting in a public toilet. She had engaged intermittently with methadone programs and expressed a re…
42y · Female·Choking on a food bolus
Deva Frijlink, aged 42 years with intellectual disability and schizoaffective disorder, died from choking on a food bolus during a supervised mealtime excursion. She was under the care of a support worker at a shared acc…
38y · Male·mixed drug toxicity and arrhythmogenic right ventricular dysplasia
Shane Andrew Kromwyk, aged 38, died at home on 14 March 2009 while on home detention bail. Post-mortem examination revealed mixed drug toxicity (methadone, diazepam, alprazolam) combined with pre-existing arrhythmogenic …
47y · Male·Multidrug toxicity (ethanol, quetiapine, baclofen, benzodiazepines)
Stuart Noble, 47, died from multidrug toxicity involving baclofen, quetiapine, benzodiazepines, and ethanol in an intentional overdose. He was prescribed baclofen off-label by his GP for alcohol use disorder despite it l…
41y · Female·Combined Drug Toxicity (ethanol and benzodiazepine)
Narisha Faye Cash, 41-year-old Aboriginal woman, died on 26 March 2020 from combined drug toxicity (ethanol and benzodiazepines) following an inadequate emergency services response to her mental health crisis. She called…
36y · Female·respiratory depression after loss of consciousness caused by mixed drug toxicity…
Rebecca Maher, a 36-year-old Aboriginal woman, died from respiratory depression caused by mixed drug toxicity (high levels of Alprazolam and Methadone) while detained as an intoxicated…
37y · Male·Mixed drug toxicity (heroin, methadone and diazepam) in a man with coronary arte…
…dule 8 drugs. These systemic failures created conditions enabling dangerous self-administration of multiple CNS depressants.
28y · Female·bronchopneumonia complicating oxycodone toxicity
…l guidance and increasing absorption rate. Oxycontin combined with diazepam created additive respiratory depression. Poor medication governance at the residential facility allowed unclear administration. The death was li…
30y · Female·Hypoxic ischaemic encephalopathy complicating cardiac arrest of unknown aetiolog…
…intoxication (nausea, vomiting, drowsiness). While asleep that night, she likely experienced respiratory depression from the combination of buprenorphine, obesity, likely sleep apnoea, and quetiapine. Clinical lessons: (…
14y · Female·Acute cerebral hypoxia arising out of suffocation due to inhalation of toxic vap…
…and bronchopneumonia. Clinical lessons: volatile substance abuse poses immediate life-threatening risks via CNS depression, asphyxiation, and hypoxia. Early recognition of warning signs (unusual deodorant smell, behavio…
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