43y · Male·Amitriptyline toxicity
…c suicidal ideation, borderline personality disorder, and a documented history of medication hoarding and overdose attempts, died from amitriptyline toxicity in April 2021. He accumulated approximately 21 days' worth of …
69y · Male·amitriptyline and alcohol toxicity with ischaemic heart disease
… 69-year-old man with longstanding anxiety, depression, heavy alcohol use, and multiple prior intentional overdoses of amitriptyline died from combined amitriptyline and alcohol toxicity with underlying ischaemic heart d…
43y · Female·Severe diffuse hypoxic brain injury caused by administration of supratherapeutic…
…diffuse hypoxic brain injury caused by excessive sodium bicarbonate administration during treatment of amitriptyline overdose. The treating ED consultant prescribed sodium bicarbonate at 2 mmol/kg repeated every 3-5 min…
52y · Male·Polypharmacy overdose of amitriptyline and doxylamine in the context of underlyi…
…ular disease and obstructive sleep apnoea died following restraint in ICU. He had ingested a polypharmacy overdose of amitriptyline and doxylamine on 26-27 February 2017, was admitted to Nepean Hospital, and successfully…
44y · Female·mixed drug toxicity with aspiration of gastric contents
…g toxicity with aspiration of gastric contents. She had been prescribed multiple medications including amitriptyline, diazepam, codeine, and lorazepam, with post-mortem toxicology showing potentially lethal levels of am…
49y · Female·combined prescription drug intoxication (zopiclone, amitriptyline, periciazine)
Karen Tracey Reaks, aged 49, died from combined prescription drug intoxication involving zopiclone, amitriptyline, and periciazine, with systemic lupus erythematosus as a contributing factor. She ingested medications…
47y · Male·Drug toxicity in the setting of restraint
…ring a mental health crisis. The expert panel concluded his death resulted from polypharmacy toxicity (amitriptyline, venlafaxine, quetiapine, tramadol) combined with physical restraint. Paramedics provided appropriate …
32y · Female·combined drug toxicity, mainly heroin
…ivate spaces with a visitor of known drug involvement, and failure to educate patients and visitors about overdose risks after abstinence. Heroin's interaction with her prescribed psychotropic medications (diazepam, amit…
24y · Male·Aspiration of vomit associated with combined drug effect
…ne alerts), tested positive for amphetamines, and attempted suicide on 4 January 2001 by overdosing on amitriptyline. After psychiatric clearance, he was discharged to his parents' care under new home detention conditio…
43y · Female·acute toxic effects of amitriptyline
A 43-year-old woman with depression was admitted to Gold Coast University Hospital with suspected amitriptyline overdose. After 11 hours of ED monitoring, she was medically cleared and transferred to a mental healt…
53y · Female·Combined effects of alcohol, amitriptyline, and methadone
Joanne Lovelock, a 53-year-old woman with chronic pain, died from combined effects of alcohol, amitriptyline, and methadone on Christmas Day 2015. She had developed opioid dependence while receiving legitimate p…
56y · Female·Acute combined drug toxicity
…ut wished to persevere with tramadol. Toxicology showed very high tramadol concentrations consistent with overdose, likely from taking larger than prescribed amounts to manage pain. She fell in her bathroom while intoxic…
56y · Female·combined drug toxicity (methadone, diazepam, amitriptyline and mirtazapine); pul…
Marianne Steer, 56, died from combined drug toxicity involving methadone, diazepam, amitriptyline, and mirtazapine. She had a long history of substance dependence and had voluntarily ceased methadone …
44y · Female·Mixed alcohol and drug toxicity (tapentadol, diazepam, mirtazapine, amitriptylin…
Aisha Natasha Khan, 44, died from mixed alcohol and drug toxicity following an intentional polypharmacy overdose with alcohol consumption. She had a history of depression, alcohol use disorder, chronic pain, and two pr…
31y · Male·Combined Drug Toxicity (amitriptyline and metoclopramide)
Bo Zhao, a 31-year-old business owner, died from combined drug toxicity (amitriptyline and metoclopramide) in a hotel room on 28 February 2019. He was facing serious criminal charges for fr…
57y · Male·Mixed drug toxicity (heroin, methadone, benzodiazepines including novel benzodia…
…done, prescribed diazepam, unprescribed benzodiazepines including the novel benzodiazepine bromazolam, amitriptyline, and olanzapine. He consumed counterfeit Xanax tablets containing bromazolam obtained from unregulated…
54y · Male·Methadone use in a man with asthma and sarcoidosis of the lungs
… methadone diversion represents a substantial public health problem, with one-third of methadone-involved overdose deaths in 2018 involving diverted drug. Key clinical lessons include the high overdose risk of methadone …
48y · Female·Mixed drug toxicity (morphine, codeine, venlafaxine, amitriptyline and zopiclone…
…ring initial assessment. During day leave on 23 April 2023, she obtained drugs and subsequently died from overdose involving morphine, codeine, venlafaxine, amitriptyline, and zopiclone. Critical clinical lessons include…
59y · Male·Unascertained
…fentanyl, benzodiazepines, alcohol, and THC. Possible causes included intentional or unintentional opioid overdose, or cardiac/respiratory complications. He had chronic dysthymia, social isolation, and poor engagement wi…
33y · Male·multi-drug toxicity as a result of misadventure
…sorder, poly-substance abuse, and a complex psychiatric history including recurrent suicidal ideation and overdoses, died from multi-drug toxicity in October 2009. The coroner examined whether his discharge on 13, 19, 21…
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