3 results for “DPD deficiency”
65y · Male·Severe neutropenic sepsis and multi-organ failure secondary to severe mucositis …
…om severe neutropenic sepsis and multi-organ failure secondary to probable dihydropyrimidine dehydrogenase (DPD) deficiency when treated with capecitabine chemotherapy. He developed severe mucositis and systemic toxicit…
64y · Male·Colonic adenocarcinoma and its treatment
…dney injury, multi-organ failure, and septic shock, dying after 14 days. The likely cause was an undetected DPD enzyme deficiency, preventing normal drug metabolism. The coroner found the care provided was appropriate b…
52y · Female·Neutropenic sepsis leading to multi-organ failure due to capecitabine toxicity
… hours). Key clinical lessons include: recognising early capecitabine toxicity signs, lack of pre-treatment DPD enzyme deficiency screening, delayed consideration and administration of the specific antidote, and communi…
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