28 results for “morphine tolerance”
56y · Male·Complications of intravenous drug use
…a couch after an evening where witnesses noted he appeared heavily sedated. Post-mortem toxicology showed morphine in the toxic/fatal range. Autopsy revealed severe pulmonary hypertension from IV drug use, empyema, emphy…
44y · Female·Heroin toxicity
…uring approved leave, she used heroin intravenously and overdosed. Critical learning: her lowered opioid tolerance from three years of abstinence meant she did not adjust her heroin dose, creating high overdose risk. Th…
54y · Female·combined drug toxicity (heroin, morphine, cannabis, and prescription medications…
…c effects of heroin combined with her regular prescription medications, likely in the context of reduced tolerance to opioids. Clinicians should remain vigilant for substance relapse in patients with addictive histories…
38y · Male·Toxicity to heroin
… clinical lesson: recently released prisoners face markedly elevated overdose risk due to reduced opioid tolerance after enforced abstinence, combined with access to more potent drugs and potential purity variations. De…
66y · Male·Coronary atherosclerosis
…y atherosclerosis on 24 February 2004, shortly after day surgery to replace a catheter on his intrathecal morphine pump. Dr R. and RN Couper administered a 0.26ml overdose of morphine during post-operative pump priming d…
44y · Male·Heroin toxicity in the setting of ischaemic heart disease
…ng poor compliance history. Within hours of release, he obtained heroin and used it, likely with reduced tolerance after prison abstinence. Key clinical lessons: (1) recently released prisoners face markedly elevated ov…
34y · Male·Mixed drug toxicity
…e parole supervision. Clinical lessons include: recently released prisoners have markedly decreased drug tolerance after period of abstinence while incarcerated, making them vulnerable to fatal overdose; FDS attended a …
28y · Female·Mixed drug toxicity
… heroin and consuming amphetamines. Toxicology revealed potentially fatal levels of methylamphetamine and morphine, plus codeine, diazepam, and benzodiazepines. The coroner found no evidence of suicidal intent, determini…
0y · Female·Perinatal asphyxia
…h gestational diabetes during pregnancy due to a pathology laboratory system error (two of three glucose tolerance test results not downloaded to patient file) combined with Western Health's failure to follow up missing…
54y · Female·mixed drug toxicity
A 54-year-old nurse with chronic pain from a 1990 back injury died from mixed drug toxicity involving morphine, codeine, doxylamine and nitrazepam. She was prescribed multiple CNS depressants for years despite being …
78y · Male·Cerebral infarction and hypoxic brain damage due to the combined effects of isch…
…umonia and opioid-related complications. He was admitted to an aged care home and commenced on MS Contin (morphine) 30mg daily by his GP for chronic pain, replacing tramadol. Critical clinical errors included: initiating…
29y · Female·respiratory depression caused by morphine intoxication on a background of upper …
…old woman with infectious mononucleosis and severe sore throat died from respiratory depression caused by morphine intoxication with concurrent upper airway narrowing. A GP administered 30mg intramuscular morphine twice …
36y · Male·mixed drug toxicity including heroin and methamphetamine
A 36-year-old man with a history of intravenous drug use died from mixed drug toxicity involving heroin and methamphetamine. He was recently released on parole and appeared to be reintegrating successfully. During a trip…
27y · Male·heroin toxicity
A 27-year-old man died from heroin toxicity while on home detention bail. He had a history of depression, anxiety, and substance use (cannabis, methamphetamine, heroin). During home detention, he was compliant, engaged w…
55y · Male·Morphine toxicity, with contributing factors of ischemic heart disease, coronary…
Shane Paul Krog, a 55-year-old man, died from morphine toxicity complicated by ischemic heart disease, coronary atherosclerosis and rhabdomyolysis. He presented…
32y · Male·Multiple drug toxicity (including heroin)
…ificantly increase overdose risk. The combination of recently paroled status (associated with low opioid tolerance), takeaway methadone access, benzodiazepines, and heroin created a deadly mix. The coroner identified th…
34y · Male·heroin toxicity with possible contribution from coronary atherosclerosis
Darren Fitzgerald, a 34-year-old lifer serving for murder, died in Woodford Correctional Centre from heroin toxicity with possible contribution from coronary atherosclerosis. He had a documented history of drug abuse in …
79y · Female·Chronic obstructive pulmonary disease
…rated with respiratory distress, a Clinical Nurse Consultant (CNC) and the treating GP agreed to commence morphine and midazolam without the GP conducting a physical review. The CNC administered the highest doses in the …
35y · Female·methadone toxicity
Melissa Irwin, 35, died from methadone toxicity after consuming her cousin's take-home methadone dose (110mg liquid). She had no history of substance abuse and had never received formal education about methadone's risks,…
44y · Female·Unascertained
A 44-year-old woman with chronic pain, epilepsy, and opioid dependence died at home with an unascertained cause in the setting of prescription medication use. She was a known 'doctor shopper' who obtained opioids from mu…
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