Frank Maurice Whittington, aged 66, died from coronary atherosclerosis on 24 February 2004, shortly after day surgery to replace a catheter on his intrathecal morphine pump. Dr Rossato and RN Couper administered a 0.26ml overdose of morphine during post-operative pump priming due to reliance on Medtronic's calculation worksheet, which failed to account for fluid already present in the pump's internal tubing in previously-primed devices. While the overdose was established, the coroner found it did not contribute to death in this highly morphine-tolerant patient. The underlying coronary artery disease and a massive meal consumed post-operatively triggered the fatal heart attack. Key clinical lessons: manufacturers must provide clear, context-specific guidance for device programming; clinicians should verify calculations independently; and pre-existing cardiac disease may remain asymptomatic despite severe pathology, particularly in pain patients receiving excellent analgesia from intrathecal delivery.
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intrathecal catheter replacementpump refilling and reprogramminglumbar punctureabdominal wound reopening
Contributing factors
Calculation error in post-operative morphine pump bolus dose
Medtronic calculation worksheet did not account for pre-filled internal tubing volume in previously-primed pumps
Chronic coronary artery disease with significant atheroma
Large meal consumption post-operatively
Inadequate pre-operative cardiac assessment despite 1998 chest pain history
Coroner's recommendations
Section 5 of the Medtronic Manual 'Pump Implant: Critical Tasks and Procedures' should be amended to include a warning that the Postoperative Bolus Dose calculation procedure must be modified for previously-primed pumps to account for the 0.26ml internal tubing volume
A second Postoperative Priming Bolus Calculation Worksheet should be developed for previously-primed pumps and added to the References and Resources section of Section 5 of the Manual
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