Coronial
SAhospital

Coroner's Finding: HERBERT Raelene Vicki

Deceased

Raelene Vicki Herbert

Demographics

29y, female

Date of death

2003-09-03

Finding date

2006-07-17

Cause of death

respiratory depression caused by morphine intoxication on a background of upper airways narrowing as a consequence of infectious mononucleosis

AI-generated summary

A 29-year-old woman with infectious mononucleosis and severe sore throat died from respiratory depression caused by morphine intoxication with concurrent upper airway narrowing. A GP administered 30mg intramuscular morphine twice within 12 hours (2 doses totalling 60mg) based on an outdated weight-based dosing calculation rather than the recommended age-based approach (7.5-15mg for a 29-year-old). The woman was morphine-naïve, making her vulnerable to respiratory depression. At hospital admission, nursing observations were inadequate: the door was closed, two nurses miscommunicated about monitoring duties, and no observations were documented for over 2 hours. Peak morphine concentration coincided with the 2am check that was not performed. Critical lessons include: correct morphine dosing based on age not weight; morphine contraindicated in acute migraine; mandatory documented observation protocols when opioids administered, especially in morphine-naïve patients; clear nurse communication and supervision. The coroner found suitable guidelines could have prevented this death.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

general practiceemergency medicinegeneral medicinepharmacologypathology

Error types

medicationdiagnosticcommunicationdelaysystem

Drugs involved

morphinemetoclopramideprochlorperazinepenicillinibuprofen

Clinical conditions

infectious mononucleosisacute bacterial tonsillitisupper airway narrowingrespiratory depressionmorphine intoxicationmigrainecervical lymphadenopathysplenomegaly

Procedures

intramuscular morphine injectionblood sample collectionintubationresuscitation

Contributing factors

  • excessive morphine dosing (30mg twice) based on incorrect weight-based calculation rather than age-based dosing
  • morphine administration in a morphine-naïve patient without appropriate tolerance
  • morphine use for acute migraine contrary to guidelines (should only be last resort)
  • failure to assess prior oral analgesia response before prescribing morphine
  • second dose of morphine given by telephone without direct patient examination
  • inadequate handover communication from Dr Kurtzer to hospital staff about morphine administration
  • inadequate nursing observations post-morphine administration (no checks for 2+ hours)
  • nursing communication failure between two nurses regarding monitoring duties
  • door closed limiting ability to detect respiratory distress
  • no documented sedation score or respiratory rate monitoring despite narcotic administration
  • marked tonsillar enlargement from infectious mononucleosis creating upper airway narrowing
  • additional sedating medications (Maxolon, Stemetil) increasing respiratory depression risk
  • absence of guidelines for safe opioid administration at regional hospital

Coroner's recommendations

  1. The Minister for Health should give consideration to how the Department might provide assistance in regular dissemination of information to Directors of Nursing in regional hospitals concerning developments relevant to patient safety and welfare to promote consistency of practice between larger hospitals and regional hospitals.
  2. The Minister for Health should make necessary arrangements as soon as possible to ensure that all hospitals within the State are alerted to the Royal Adelaide Hospital guidelines for the administration of intermittent subcutaneous and intravenous opioid administration for acute pain management.
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