Coronial
WAhospital

Inquest into the Death of Anne RZEPCZYNSKI

Deceased

Anne RZEPCZYNSKI

Demographics

59y, female

Coroner

Coroner King

Date of death

2012-02-20

Finding date

2018-06-14

Cause of death

complications of intra-abdominal sepsis, including multi-organ failure and bowel perforation, following median hepatectomy for cholangiocarcinoma

AI-generated summary

59-year-old woman died from intra-abdominal sepsis, multi-organ failure and bowel perforation following median hepatectomy for cholangiocarcinoma. Key clinical issues included: surgical delays of 20 days between stent insertion and operation (affecting bile duct inflammation and infection risk); post-operative complications of arterial bleeding requiring re-operation; bile leak from anastomoses; conservative management of intra-abdominal collections with delayed intervention; lack of specialist liver surgeon during post-operative period; and inadequate nutrition for approximately 10 days. While the coroner found post-operative care generally reasonable, independent experts identified failures: not performing CT scan and starting antibiotics on 3 January when intra-abdominal collections and elevated infection markers were identified; and delay in draining infected collections until 20 January. The combination of pre-operative delay, post-operative bleeding, bile leak, sepsis, and nutritional deficiency created a cascading spiral of complications.

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Specialties

general surgeryintensive caregastroenterologyradiologyanaesthesiadietetics

Error types

diagnosticdelaysystem

Drugs involved

antibioticstotal parenteral nutritionalbuminfresh frozen plasmapacked red blood cellsplateletsdiureticsinotropesantifungals

Clinical conditions

cholangiocarcinoma (klatskin tumour)bile duct obstructionascending cholangitisintra-abdominal sepsispolymicrobial infectionpost-operative arterial haemorrhagebile leakhepatic ischaemiapleural effusionrespiratory failureacute renal failuremulti-organ failurebowel perforationcolonic ischaemiaseptic shockcoagulopathyileus

Procedures

endoscopic retrograde cholangiopancreatography with stent insertionmedian hepatectomyhepaticojejunal anastomosisemergency laparotomy for haemostasisradiologically guided pigtail drain insertionintercostal catheter insertion for pleural drainageexploratory laparotomy with colectomy and colostomy formationtracheostomy

Contributing factors

  • surgical postponement of 20 days after stent insertion, increasing risk of bile duct inflammation and infection
  • post-operative arterial bleeding requiring emergency re-operation on day 1 post-surgery
  • bile leak from hepaticojejunal anastomoses following re-operation
  • intra-abdominal collections with polymicrobial sepsis
  • conservative management without early CT scan or antibiotics despite ultrasound evidence of collections on 3 January
  • delayed drainage of infected collections (first drain inserted 20 January)
  • absence of specialist liver surgeon during post-operative management period
  • Dr R. on annual leave for first two weeks post-operatively
  • inadequate nutrition for approximately 10 days
  • large bilateral pleural effusions and respiratory failure
  • bowel ischaemia and perforation requiring colectomy
  • multi-resistant organisms developing later in admission

Coroner's recommendations

  1. Royal Australasian College of Surgeons and Australian and New Zealand Hepatic, Pancreatic and Biliary Association should provide guidelines on timing of surgery following bile duct stent insertion if they have not done so already
  2. If the Royal Australasian College of Surgeons determines similar surgeries should occur within very limited time, Health Department and National Health Ministers' Advisory Council should reflect this in elective surgery urgency categorisation policies
  3. Continued employment of additional liver surgeons at Royal Perth Hospital to ensure specialist post-operative oversight availability
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