complications of intra-abdominal sepsis, including multi-organ failure and bowel perforation, following median hepatectomy for cholangiocarcinoma
AI-generated summary
59-year-old woman died from intra-abdominal sepsis, multi-organ failure and bowel perforation following median hepatectomy for cholangiocarcinoma. Key clinical issues included: surgical delays of 20 days between stent insertion and operation (affecting bile duct inflammation and infection risk); post-operative complications of arterial bleeding requiring re-operation; bile leak from anastomoses; conservative management of intra-abdominal collections with delayed intervention; lack of specialist liver surgeon during post-operative period; and inadequate nutrition for approximately 10 days. While the coroner found post-operative care generally reasonable, independent experts identified failures: not performing CT scan and starting antibiotics on 3 January when intra-abdominal collections and elevated infection markers were identified; and delay in draining infected collections until 20 January. The combination of pre-operative delay, post-operative bleeding, bile leak, sepsis, and nutritional deficiency created a cascading spiral of complications.
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Specialties
general surgeryintensive caregastroenterologyradiologyanaesthesiadietetics
Error types
diagnosticdelaysystem
Drugs involved
antibioticstotal parenteral nutritionalbuminfresh frozen plasmapacked red blood cellsplateletsdiureticsinotropesantifungals
endoscopic retrograde cholangiopancreatography with stent insertionmedian hepatectomyhepaticojejunal anastomosisemergency laparotomy for haemostasisradiologically guided pigtail drain insertionintercostal catheter insertion for pleural drainageexploratory laparotomy with colectomy and colostomy formationtracheostomy
Contributing factors
surgical postponement of 20 days after stent insertion, increasing risk of bile duct inflammation and infection
post-operative arterial bleeding requiring emergency re-operation on day 1 post-surgery
bile leak from hepaticojejunal anastomoses following re-operation
intra-abdominal collections with polymicrobial sepsis
conservative management without early CT scan or antibiotics despite ultrasound evidence of collections on 3 January
delayed drainage of infected collections (first drain inserted 20 January)
absence of specialist liver surgeon during post-operative management period
Dr R. on annual leave for first two weeks post-operatively
inadequate nutrition for approximately 10 days
large bilateral pleural effusions and respiratory failure
bowel ischaemia and perforation requiring colectomy
multi-resistant organisms developing later in admission
Coroner's recommendations
Royal Australasian College of Surgeons and Australian and New Zealand Hepatic, Pancreatic and Biliary Association should provide guidelines on timing of surgery following bile duct stent insertion if they have not done so already
If the Royal Australasian College of Surgeons determines similar surgeries should occur within very limited time, Health Department and National Health Ministers' Advisory Council should reflect this in elective surgery urgency categorisation policies
Continued employment of additional liver surgeons at Royal Perth Hospital to ensure specialist post-operative oversight availability
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