Coronial
WAhospital

Inquest into the Death of Daniel LAHENGKING

Deceased

Daniel LAHENGKING

Demographics

66y, male

Coroner

Coroner King

Date of death

2009-08-15

Finding date

2014-08-29

Cause of death

multiple organ failure associated with the combined effects of complications of methotrexate toxicity, vasculitis and atherosclerotic cardiovascular disease

AI-generated summary

Daniel Lahengking, a 66-year-old Indonesian visiting family in Esperance, was diagnosed with rheumatoid arthritis by locum GP Dr H. and prescribed methotrexate 5-10mg daily, a grossly excessive dose (normal: 7.5-20mg weekly). The pharmacist dispensed it without proper labelling after flagging concerns but failing to resolve them effectively. The patient developed severe toxicity with vomiting, diarrhoea and mouth ulcers. When he returned with symptoms, Dr H. misdiagnosed urinary tract infection and failed to investigate the methotrexate. He was later hospitalized with severe immunosuppression, triggering tuberculosis reactivation, gastrointestinal bleeding and sepsis. Although the immediate methotrexate toxicity resolved, subsequent complications including vasculitis and coronary artery disease led to his death. Clinical lessons include: always obtain baseline blood tests before methotrexate; consider medication toxicity in differential diagnosis; pharmacists must effectively escalate safety concerns about unusual prescriptions; and methotrexate carries serious toxicity risks requiring careful patient selection and monitoring.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

general practicepharmacyemergency medicinegeneral medicinerheumatologyintensive care

Error types

diagnosticmedicationcommunication

Drugs involved

methotrexatecelecoxibtoradolcelestone chronodose

Clinical conditions

methotrexate toxicitypancytopeniasepticemiatuberculosisgastrointestinal bleedingvasculitisatherosclerotic cardiovascular diseasegoutrenal impairmentbone marrow depressionsmall bowel obstruction

Procedures

laparotomygastroscopycontinuous venovenous haemodialysisnephrectomy

Contributing factors

  • methotrexate prescribed at grossly excessive dosage (5-10mg daily vs normal 7.5-20mg weekly)
  • failure to obtain baseline blood tests before prescribing methotrexate
  • failure to confirm diagnosis of rheumatoid arthritis (actually had gout)
  • failure to recognize methotrexate toxicity when patient presented with classic symptoms
  • failure to escalate safety concern by pharmacist about unusual prescription
  • inadequate labelling of methotrexate container
  • methotrexate-induced immunosuppression leading to tuberculosis reactivation
  • patient's small body weight (50kg) not factored into dosing
  • renal impairment (staghorn calculus in right kidney) increasing effective methotrexate dose
  • physician fatigue and iron deficiency affecting prescriber judgment

Coroner's recommendations

  1. Referral to Australian Health Practitioner Regulatory Agency under s50 of the Coroners Act 1996
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