Left-sided intracerebral haemorrhage associated with deep brain stimulator wire tract
AI-generated summary
A 64-year-old man died from intracerebral haemorrhage along a deep brain stimulator wire tract four days after elective neurosurgery for essential tremor. He was readmitted on day 4 with suspected stroke and started on therapeutic anticoagulation (enoxaparin). A haemorrhage developed within 24 hours of dose escalation. Key clinical failures: the prescribed enoxaparin dose (120mg twice daily) exceeded the guideline-recommended dose for his lean body weight (107mg twice daily); antiXa levels were not checked at appropriate timepoints to verify therapeutic range; specialist haematology oversight was not obtained despite obesity and renal impairment making enoxaparin pharmacokinetics unpredictable. An alternative strategy—delaying DBS until a Watchman device insertion for atrial fibrillation—was identified but not pursued. Clinicians should calculate anticoagulation doses by lean body weight in obese patients, obtain specialist oversight for complex cases, and monitor antiXa levels appropriately.
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deep brain stimulator insertioncomputed tomography brain imaging
Contributing factors
Enoxaparin dose exceeded guideline recommendation (120mg twice daily versus calculated 107mg twice daily based on lean body weight)
Failure to obtain haematology specialist oversight despite obesity and chronic kidney disease making anticoagulant pharmacokinetics unpredictable
Anticoagulation antiXa levels not obtained at appropriate time intervals to verify therapeutic range
Anticoagulation initiated in high-risk patient (obesity, chronic renal impairment, recent neurosurgery) without adequate monitoring protocol
Lack of documentation of clear post-discharge anticoagulation plan following DBS procedure
Alternative clinical strategy (postponing DBS until Watchman device insertion) not pursued despite being identified
Coroner's recommendations
Monash Clinical Council to support the proposed Hospital-wide anticoagulant stewardship program to provide systemic, collaborative approach to safe and optimal anticoagulant therapy
Copies of finding to be provided to Safer Care Victoria and Pharmacy Guild to share ongoing learning regarding dangers of high-risk medications
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