A 7-hour-old neonate died from early-onset Group B Streptococcus (GBS) infection contracted during labour. The mother's GBS screening test at 35-37 weeks gestation was reported negative, and no antibiotic prophylaxis was administered during labour despite prolonged rupture of membranes (43 hours) and significant labour duration (17 hours). The coroner found the death preventable—if antibiotics had been given, the infant would likely have survived. Key issues include: reliance on a falsely negative screening result; failure to recognize that risk factors (prolonged PROM) persist despite negative screening; lack of informed consent discussion; and South Australian guidelines that failed to address false negatives. The coroner recommended amended guidelines to administer prophylactic antibiotics to GBS-negative women with prolonged PROM (≥18-24 hours), improved informed consent processes, and development of rapid intrapartum GBS testing.
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Group B Streptococcus infectionearly-onset neonatal sepsispre-labour rupture of membranesprolonged rupture of membranespneumoniabacteraemianeonatal shock
Procedures
vaginal examinationscalp electrode applicationventouse suction deliveryGBS screening test
Contributing factors
False negative GBS screening test result
Failure to recognize prolonged rupture of membranes as a risk factor despite negative screening
Absence of antibiotic prophylaxis during labour
No induction of labour despite 43-hour post-PROM period
Multiple internal vaginal examinations during labour increasing infection risk
Scalp electrode application increasing risk of ascending infection
South Australian Department of Health guidelines that did not recommend antibiotics for GBS-negative women with prolonged PROM
Lack of informed consent discussion regarding GBS risk and antibiotic options
Coroner's recommendations
The South Australian Minister for Health, Department of Health, and Medical Board of South Australia should bring findings to the attention of the medical profession, specifically highlighting the incidence of false negative GBS screening results and the potential adverse consequences of relying solely on reported negative results
The South Australian Department of Health should amend its guidelines on intrapartum antibiotic prophylaxis to recommend antibiotic prophylactic cover for women at term who are reportedly GBS-negative but have prolonged rupture of membranes greater than 18 hours (or 24 hours if considered more appropriate), notwithstanding the reported negativity of their test
Include reference in guidelines to the incidence of false negative GBS screening test results
Include reference in guidelines to suggest clinicians consider advising induction in cases of term PROM
Encourage clinicians to involve women and their partners in decision-making regarding antibiotic prophylaxis and induction
The South Australian Department of Health should consider whether GBS screening examinations should involve taking an anal swab in addition to a low vaginal swab
The South Australian Department of Health should participate in and continue to monitor development of more accurate screening methods for GBS, particularly rapid intrapartum testing methods
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