Acute myocardial infarction precipitated by upper gastrointestinal haemorrhage from gastric ulcer in context of rivaroxaban therapy
AI-generated summary
An 84-year-old man with multiple comorbidities was prescribed rivaroxaban for deep vein thrombosis despite being a practicing Jehovah's Witness who refused blood transfusions. Rivaroxaban cannot be monitored or reversed, unlike warfarin. He developed upper gastrointestinal bleeding from a gastric ulcer, possibly exacerbated by concurrent use of a naturopathic cherry juice product and rivaroxaban. Symptoms were masked and presented as anaemia. Critical learning points: anticoagulant choice should consider patient's transfusion refusal status; clinical discharge summaries must reach GPs; a 40% haemoglobin drop warrants urgent action rather than waiting for specialist review; and symptoms of GI bleeding can be subtle in elderly patients on anticoagulants.
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Specialties
cardiologyhaematologygastroenterologyintensive caregeneral practiceemergency medicine
Error types
medicationcommunicationdiagnosticdelay
Drugs involved
rivaroxabanenoxaparinwarfarincolchicinenature's goodness joint formula cherry juice concentrate with anthocyanin complexerythropoietinphytomenadionetranexamic acidproton pump inhibitoradrenaline
doppler ultrasoundupper gastrointestinal endoscopyendoscopic injection of adrenalineemergency resuscitation
Contributing factors
Prescription of rivaroxaban (non-reversible anticoagulant) to patient with faith-based refusal of blood products
Lack of discussion with patient about anticoagulation risks and transfusion implications
Concurrent use of naturopathic cherry juice product masking symptoms
Failure to provide clinical discharge summary to general practitioner
Delayed recognition of upper gastrointestinal bleeding by general practitioner
Missed opportunity for earlier escalation after 40% haemoglobin drop on 11 March 2015
Acute kidney injury making rivaroxaban less suitable than warfarin
Coroner's recommendations
Ensure clinician discussion with any patient started on anticoagulation therapy about treatment risks, lack of reversal agents for new oral anticoagulants, and patient's position on accepting blood transfusions
Ensure hospital pharmacy department involvement in patient education about anticoagulant risks with documentation in patient chart
Require documentation in patient chart of commencement of therapy and reasons for medication decisions
Improve documentation of discussions to confirm patient understanding and acceptance of treatment
Better document patient requests regarding treatment and discharge preferences
Improve communication within treating teams, particularly regarding medication changes and clinical reasoning
Advocate for changes to national medication chart patient education box to include reference to new oral anticoagulants and reversal agent status
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