Coronial

2 results for “DPD enzyme deficiency”

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QLDhospitalNew2026-07-02

Inquest into the death of Jeffrey Stewart Olsen

64y · Male·Colonic adenocarcinoma and its treatment

…dney injury, multi-organ failure, and septic shock, dying after 14 days. The likely cause was an undetected DPD enzyme deficiency, preventing normal drug metabolism. The coroner found the care provided was appropriate b…

oncologygeneral surgerycapecitabine
VIChospital2021-01-28

Finding into death of MrsL

52y · Female·Neutropenic sepsis leading to multi-organ failure due to capecitabine toxicity

… hours). Key clinical lessons include: recognising early capecitabine toxicity signs, lack of pre-treatment DPD enzyme deficiency screening, delayed consideration and administration of the specific antidote, and communi…

oncologyradiation oncologydiagnosticdelaycapecitabine

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