Dilated cardiomyopathy with previous aortic valve replacement and aortic graft
AI-generated summary
A 68-year-old man with aortic valve replacement died from undiagnosed dilated cardiomyopathy, with retroperitoneal haemorrhage as a contributing factor. He developed a large perinephric haematoma (1900mL) secondary to over-anticoagulation (INR 3.5, prothrombin 49 seconds) from warfarin. His GP did not receive anticoagulation monitoring results from Austin Health, limiting ability to adjust warfarin dosing. In ED, a registrar appropriately identified over-anticoagulation before CT diagnosis and proactively ordered reversal agents, though Prothrombinex dosing was not documented. Hospital management was appropriate; the haematoma stabilized and patient remained stable until sudden collapse on day 3 in hospital. The preventable clinical lesson is that GPs managing warfarin patients must ensure receipt of INR results and remain alert to bruising and abdominal pain as bleeding signs, especially with elevated INR. ED identification of warfarin toxicity was exemplary.
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Specialties
cardiothoracic surgeryemergency medicineurologycardiologygeneral practice
Error types
communicationsystemmedication
Drugs involved
warfarinatenololpiroxicamaspirintramadolpropoxypheneparacetamolprothrombinexfresh frozen plasmapacked red blood cellsoxycodoneoxycodone
Clinical conditions
dilated cardiomyopathyover-anticoagulationwarfarin toxicityretroperitoneal haemorrhageperinephric haematomaaortic valve replacementrheumatic aortic valvular diseaseabdominal aortic aneurysm repairpolycystic kidney diseasedistal right common iliac artery aneurysm
Retroperitoneal haemorrhage secondary to over-anticoagulation
Inadequate anticoagulation monitoring by general practitioners
GP did not receive INR/prothrombin results from Austin Health
Undiagnosed severe dilated cardiomyopathy
INR over-elevation (3.5) in the four months preceding presentation
Failure to document Prothrombinex dose on initial order
Failure to administer Vitamin K with Prothrombinex reversal
Coroner's recommendations
No formal recommendations made. Northern Hospital had proactively implemented new Prothrombinex guidelines (17 November 2010), introduced mandatory protocol for anticoagulation reversal (April 2010), conducted audit of Prothrombinex dosing (2011), and committed to six-monthly compliance audits.
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