1 result for “oxidative stress”
Finding into death of Danielle Cadan
51y · Female·Methemoglobinemia in the context of lignocaine use
Danielle Cadan, 51, died from methemoglobinemia following a tooth extraction under lignocaine anaesthetic at a regional health service. The lignocaine was administered in normal therapeutic dose but triggered this rare life-threatening complication. The coroner found clinical care reasonable and antibiotics were not indicated. However, inadequate discharge advice was identified as a critical gap. Danielle experienced alarming symptoms (feeling 'cold to bone', shivering, racing heart) post-procedure but lacked written guidance about when to seek emergency care. The coroner emphasised that enhanced discharge advice specifically warning of rare serious drug reactions and their symptoms, with explicit instruction to present to ED if concerning features develop, would have provided her best chance of survival. The case highlights that rare complications can occur even with standard doses in previously-exposed patients, necessitating robust safety-netting discharge instructions.
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