Cardiorespiratory arrest of unknown aetiology complicating hypoxic ischaemic encephalopathy in the setting of anaphylaxis
AI-generated summary
Max McKenzie, a 15-year-old with asthma and food allergies, died from cardiorespiratory arrest complicating hypoxic ischaemic encephalopathy after severe refractory anaphylaxis. After eating apple crumble containing nuts, he self-administered an EpiPen. Ambulance paramedics administered adrenaline but Max deteriorated rapidly. At hospital, emergency physicians delayed intubation for 15 minutes despite critical hypoxia, attempting to stabilise him first. A surgical airway was eventually established via cricothyroidotomy. The coroner found that while early adrenaline dosing and earlier airway establishment would have given Max the best chance of survival, his death was not preventable—he had refractory anaphylaxis with significant mortality risk even with optimal treatment. Key failures: delayed first adrenaline dose by paramedics, lack of IV adrenaline administration earlier, and delayed intubation decision by ED physicians despite obvious severe hypoxia.
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bag valve mask ventilationendotracheal intubationcricothyroidotomycardiopulmonary resuscitationextracorporeal membrane oxygenation (ECMO)tracheostomychest drainage
Contributing factors
Refractory anaphylaxis unresponsive to initial adrenaline doses
Severe bronchospasm
Delayed administration of first intramuscular adrenaline by paramedics (approximately 10 minutes after arrival rather than within 5 minutes)
Delayed establishment of intravenous adrenaline infusion
Delayed intubation attempt by emergency physicians (15 minutes after arrival)
Difficulty identifying clear team leader during resuscitation
Multiple failed intubation attempts before cricothyroidotomy
Profuse vomiting complicating airway management
Endotracheal tube positioned incorrectly in right main bronchus after cricothyroidotomy
Hypoxic seizure at scene indicating severe hypoxia
Underlying asthma as comorbidity complicating anaphylaxis management
Coroner's recommendations
Ambulance Victoria review its separate guidelines for the treatment of asthma and anaphylaxis to ensure consistency in relation to adrenaline therapy
Ambulance Victoria ensure that graduate paramedics undergo emergency driving training during their induction period before entering on-road clinical practice
Consider changes to MPDS call script to identify anaphylaxis with dual diagnosis of asthma
Develop Ambulance Victoria Escalation of Care Clinical Practice Guidelines
Include critically unwell paediatric education in yearly Ambulance Victoria education
Conduct thematic analysis on children with both asthma and anaphylaxis
Conduct thematic analysis of paediatric sentinel events
Emphasise state-level education on assessment and treatment of acutely unwell children at risk of deterioration
Reintroduce multidisciplinary simulation training in emergency departments for critical patient management
Contact Australian and New Zealand College of Anaesthetists to develop training scenarios for children with asthma and anaphylaxis with focus on airway management
Contact Australian College of Emergency Medicine to develop ACME simulation course scenario for dual diagnosis
Introduce mandated roles visible on uniform in emergency departments
Create policy directing unassigned staff outside resuscitation areas
Engage relevant peak bodies to review anaphylaxis guidelines in setting of asthma
Improve and standardise recording of prehospital notifications
Review procedures for simplification of handover requirements for critically unwell patients
Replace nebuliser delivery devices to prevent small parts falling during use
Update Open Disclosure standards to meet Statutory Duty of Candour requirements
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