Pulmonary thromboembolism secondary to deep venous thrombosis
AI-generated summary
A 29-year-old man died from pulmonary thromboembolism secondary to deep vein thrombosis (DVT) following a suicide attempt by hanging. He was admitted to ICU and appropriately commenced on prophylactic enoxaparin 40mg daily. On day 3 of admission, due to aggressive behaviour and staff safety concerns, enoxaparin was ceased to facilitate de-escalation. The patient remained in ICU (rather than transferring to psychiatric unit due to bed unavailability) and was mechanically restrained, limiting mobility. DVT developed early in admission, likely before enoxaparin cessation. Expert evidence established that prophylactic enoxaparin was probably ineffective in this case and that cessation did not cause or contribute to death. However, the case highlights gaps in clinical guidance: defining 'immobility' for VTE assessment in psychiatric patients and clarifying when oral anticoagulants (DOACs) could substitute for subcutaneous enoxaparin when safe administration is impossible.
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Specialties
intensive carepsychiatryemergency medicinehaematologygeneral medicine
Suicide attempt by hanging with period of circulatory arrest
Immobility from mechanical restraint during ICU admission
Critical illness and intubation
Prolonged stay in ICU unsuitable for ambulant psychiatric patient due to bed unavailability in psychiatric unit
Cessation of prophylactic enoxaparin on day 3 (though evidence suggests DVT began before this)
Early development of DVT despite initial prophylaxis
Coroner's recommendations
Provide finding to Australian Commission on Safety and Quality in Health Care for consideration of inclusion of a clear definition of 'immobility' in thromboprophylaxis assessment tools and clinical guidelines, with suggested threshold questions: (1) Is patient at usual level of mobility and function? (2) Is patient spending more than 14 hours per day in bed?
Provide finding to Safer Care Victoria for consideration of opportunities to engage with hospitals including Western Health and psychiatric inpatient units on immobility definition for VTE prophylaxis
Distribute finding to Thrombosis and Haemostasis Society of Australia and New Zealand, Royal Australian and New Zealand College of Psychiatrists, Royal Australasian College of Physicians, College of Intensive Care Medicine of Australia and New Zealand, Australian Commission on Safety and Quality in Health Care, and Therapeutic Goods Administration for consideration of expansion of guidance on use of direct-acting oral anticoagulants as alternative to low molecular weight heparin thromboprophylaxis in hospital settings where subcutaneous injection cannot be safely administered
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