Coronial
VICaged care

Finding into death of S M

Deceased

SM

Demographics

91y, male

Coroner

Coroner Audrey Jamieson

Date of death

2017-07-27

Finding date

2023-03-22

Cause of death

Complications of cerebrovascular and ischaemic heart disease in a man post anaphylactic reaction to diltiazem

AI-generated summary

A 91-year-old man with known diltiazem allergy was prescribed diltiazem by a geriatrician despite documented allergy records. The geriatrician relied on the patient's verbal denial of allergies despite significant dementia, without consulting medical records, the in-house GP, or family. The prescription progressed through multiple check-points where allergies were documented but not identified: a dispensing pharmacist dismissed allergy alerts, a second pharmacist failed to recognise the contraindication during sign-off, and nursing staff did not verify allergies before administration. The patient developed severe DRESS syndrome with anaphylaxis, acute kidney injury, liver dysfunction, and elevated inflammatory markers. He subsequently suffered a cerebrovascular event and died. Multiple system failures occurred across prescribing, dispensing, pharmacy software alerts, and nursing administration. Key learning: never rely on patient recall for drug allergies in elderly patients with cognitive impairment; always verify against documentation; utilise all available safety checks; and ensure clear communication across the care team.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

geriatric medicinegeneral practiceemergency medicinepharmacydermatologyintensive care

Error types

diagnosticmedicationcommunicationsystemprocedural

Drugs involved

diltiazemhydrochlorothiazidemetoprololceftriaxoneadrenalinepromethazineoxycodoneduloxetinerisperidone

Clinical conditions

anaphylaxisdrug reaction with eosinophilia and systemic symptoms (DRESS)angioedemaacute kidney injuryliver dysfunctioncerebrovascular eventischaemic heart diseaseatrial fibrillationcongestive cardiac failuredementiachronic obstructive airway diseasebronchospasm

Contributing factors

  • Prescriber failed to verify drug allergy despite documented contraindication
  • Reliance on patient's verbal confirmation of allergies despite severe dementia
  • Failure to consult medical records, in-house GP, or family regarding allergies
  • Dispensing pharmacist dismissed allergy alerts as 'not relevant' based on prior similar medication
  • Second pharmacist failed to identify contraindicated medication during sign-off
  • Pharmacy software did not prevent dispensing of contraindicated medication
  • Nursing staff did not verify allergies before administration
  • Lack of communication between prescriber and in-house GP regarding medication changes
  • Absence of generic drug name on medication packette label
  • Failure to escalate anaphylactic reaction early to senior clinician

Coroner's recommendations

  1. GM Pharmacy's Fred system should include acknowledgement and sign-off alerts for contraindicated medications
  2. MPS should alter its process to prevent packaging of medications when the system indicates a contraindication
  3. All medication chart labels should indicate generic names when brand names are displayed
  4. Every packette should be labelled with the generic name of medications
  5. Pharmacy software systems must be enhanced to ensure allergy alerts cannot be easily dismissed
  6. Best Dose feature should be implemented to highlight allergies when contraindicated medications are entered
  7. Prescribers should never rely on elderly patients with cognitive impairment to recall their drug allergies without verification against documentation
  8. Prescribers must communicate significant medication changes to supervising GPs and nursing staff immediately
  9. Enhanced training on medication safety and allergy verification for all healthcare professionals involved in aged care
  10. Formal implementation of double-check procedures at dispensing and administration stages, particularly for contraindicated medications
Full text

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