Complications of cerebrovascular and ischaemic heart disease in a man post anaphylactic reaction to diltiazem
AI-generated summary
A 91-year-old man with known diltiazem allergy was prescribed diltiazem by a geriatrician despite documented allergy records. The geriatrician relied on the patient's verbal denial of allergies despite significant dementia, without consulting medical records, the in-house GP, or family. The prescription progressed through multiple check-points where allergies were documented but not identified: a dispensing pharmacist dismissed allergy alerts, a second pharmacist failed to recognise the contraindication during sign-off, and nursing staff did not verify allergies before administration. The patient developed severe DRESS syndrome with anaphylaxis, acute kidney injury, liver dysfunction, and elevated inflammatory markers. He subsequently suffered a cerebrovascular event and died. Multiple system failures occurred across prescribing, dispensing, pharmacy software alerts, and nursing administration. Key learning: never rely on patient recall for drug allergies in elderly patients with cognitive impairment; always verify against documentation; utilise all available safety checks; and ensure clear communication across the care team.
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Specialties
geriatric medicinegeneral practiceemergency medicinepharmacydermatologyintensive care
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