Gerard Guy Vaz, a 61-year-old man with bipolar disorder, obstructive sleep apnoea, and renal impairment, was admitted to Maroondah Hospital on 2 April 2015 with acute manic relapse with psychosis. He was administered zuclopenthixol acetate on 3 April 2015 and subsequently died on 5 April 2015 from an undetermined cause. Clinical lessons include: Eastern Health sedation guidelines were not followed; vital sign monitoring ceased at 7:45am on 4 April despite guidelines requiring observations for 72 hours; no ECG was performed on 4 April despite orders and guidelines requiring ECGs at 24 hours; apnoeic episodes observed while sedated and physically restrained were not adequately escalated to intensive care monitoring; and multi-drug sedation with QT-prolonging agents without adequate cardio-respiratory monitoring in a patient with pre-existing QT prolongation and sleep apnoea represented substandard care. Adherence to existing guidelines and appropriate escalation of deteriorating patients are critical.
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Non-adherence to Eastern Health sedation guidelines regarding physical observations post-zuclopenthixol acetate injection
Cessation of vital sign monitoring at 7:45am on 4 April 2015, despite guidelines requiring observations for up to 72 hours
Absence of ECG on 4 April 2015 despite guidelines requiring ECG at 24 hours post-injection
Inadequate monitoring of apnoeic episodes occurring during sedation and physical restraint
Multi-drug sedation with three QT-prolonging anti-psychotic agents without adequate cardio-respiratory monitoring
Failure to escalate patient to intensive care or high-dependency unit despite documented respiratory deterioration
Pre-existing QT prolongation and obstructive sleep apnoea not adequately accounted for in sedation management
Hypoventilation from sedative medications combined with existing sleep apnoea
Possible cardiac arrhythmia from combination of QT-prolonging drugs in setting of hypoxia
Coroner's recommendations
Eastern Health acknowledged issues and has implemented internal recommendations: (a) review clinical practice related to management and transfer of mental health patients requiring acute interdisciplinary care, with interdisciplinary care incorporated into staff training and a perioperative and mental health liaison medicine unit established at Box Hill Hospital to facilitate close monitoring and improve pathways of escalation; (b) provide training to nursing staff in acute mental health settings and junior medical staff regarding recognition and response to patient deterioration; (c) educate mental health medical and nursing staff regarding neurological observations practice guidelines. Additionally, formalized process implemented whereby ECGs performed 24 hours after zuclopenthixol acetate injection are checked by duty psychiatry registrar and reviewed and signed off by attending medical registrar on daily basis.
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