A 52-year-old man with multiple sclerosis, chronic pain, depression and history of suicidality died from mixed drug toxicity following an intentional overdose. He was prescribed multiple opioids (fentanyl, tramadol, oxycodone), benzodiazepines, pregabalin and sertraline by multiple prescribers without coordinated oversight. PBS records revealed he obtained significantly more pregabalin and diazepam than therapeutically indicated, and received two fentanyl prescriptions only 6 days apart. Clinical lessons include: implementing real-time prescription monitoring for all drugs including pregabalin; coordinating prescribing across multiple clinicians; recognising medication misuse in patients with legitimate chronic pain; and recognising overdose signs (abnormal breathing, unarousable sleep) in witnessed cases to enable intervention.
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Specialties
general practiceneurologypain medicinepsychiatryforensic medicine
Absence of real-time prescription monitoring for pregabalin and sertraline
Chronic depression and suicidality
Chronic pain with inadequate non-pharmacological management
Financial strain and inability to maintain work capacity
Patient medication misuse and self-escalation of doses
Lack of integrated care coordination between GPs and specialists
Coroner's recommendations
Department of Health and Human Services review the rationale for excluding pregabalin from the Real Time Prescription Monitoring scheme
Department of Health and Human Services consult with the Royal Australian College of General Practitioners and other relevant bodies to consider how targeted education on overdose risk, overdose recognition and response can be provided to families and partners of people prescribed strong opioids
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