Coronial
VICother

Finding into death of Mr A

Deceased

Mr A

Demographics

24y, male

Date of death

2016

Finding date

2019-10-18

Cause of death

Mixed drug toxicity

AI-generated summary

A 24-year-old man died from mixed drug toxicity after staying overnight at a backpackers hostel. He had a history of anxiety and shoulder pain following 2015 surgery, for which he received multiple medications including pregabalin, benzodiazepines, opioids, and stimulants from different prescribers. His girlfriend observed he was taking higher doses than prescribed. The toxicology showed therapeutic levels of multiple CNS depressants (pregabalin, clonazepam, buprenorphine, pholcodine) plus dexamphetamine and bupropion. He was found unresponsive with blue lips and unable to be resuscitated. Key clinical lessons: uncoordinated prescribing across multiple doctors allowed excessive pregabalin accumulation without awareness of drug interactions; no clinician had an overview of his complete medication regimen; CNS depressant combinations (pregabalin with benzodiazepines and opioids) create fatal respiratory depression risk. The implementation of SafeScript prescription monitoring and inclusion of pregabalin would likely have prevented this death.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes.

Contributing factors

  • Uncoordinated prescribing by multiple doctors without knowledge of each other's prescriptions
  • Excessive pregabalin dispensing (440 tablets in 5 months, up to 4 tablets daily vs 1-2 prescribed)
  • Combination of CNS depressants: pregabalin, clonazepam, buprenorphine, pholcodine
  • Lack of centralised prescription monitoring system at time of death
  • Patient taking higher doses than prescribed
  • Absence of communication between treating clinicians regarding medication changes
  • Patient with history of anxiety, drug-seeking behaviour, and pharmaceutical misuse

Coroner's recommendations

  1. Victorian Department of Health and Human Services review the scope of drugs monitored in SafeScript real-time prescription monitoring program to ensure all appropriate drugs are included
  2. Victorian Department of Health and Human Services include pregabalin in the scope of drugs monitored in SafeScript real-time prescription monitoring program
  3. Finding to be provided to Ambulance Victoria for consideration regarding public education on telephone health advice options available in Victoria
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