Acute renal failure in the setting of urosepsis and San Filippo Syndrome
AI-generated summary
Stephen Blom, a 45-year-old man with San Filippo Syndrome and early-onset dementia living in a community residential unit, died from acute renal failure secondary to urosepsis. He presented with urinary tract infection symptoms on 5 May 2014, was treated with antibiotics in the community, but developed progressive lethargy, reduced urinary output, vomiting, and constipation. Despite outpatient management and investigation including abdominal imaging, clinical deterioration continued. He was admitted to hospital on 15 May 2014 where pre-renal acute kidney injury was diagnosed. Despite intravenous therapy and antibiotics, his condition was not reversible. The coroner found no issues with health management. Earlier recognition of sepsis severity and earlier hospitalisation may have been beneficial, though the underlying San Filippo Syndrome likely limited prognosis.
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