Coronial
VIChospital

Finding into death of Noela McGowan

Deceased

Noela McGowan

Demographics

66y, female

Coroner

Coroner John Olle

Date of death

2013-10-07

Finding date

2013

Cause of death

Complications following paracetamol overdose

AI-generated summary

A 66-year-old woman died from complications of paracetamol overdose after ingesting Mersyndol (codeine/paracetamol combination tablets). She had developed dependence on over-the-counter Mersyndol over approximately 8 years, using it for pain and sleep. Evidence indicated 'pharmacy shopping'—purchasing from multiple pharmacies to obtain larger quantities. Between June-September 2013, she obtained 760 tablets from one pharmacy alone. The coroner found no fault with emergency or hospital management, which appropriately treated fulminant liver failure. Key clinical lessons: pharmacists must verify therapeutic need before supplying Schedule 3 medicines, limit single packages unless exceptional circumstances exist, and be alert to pharmacy shopping. Real-time monitoring of OTC codeine sales and enhanced warning labels about paracetamol toxicity could prevent similar deaths.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

emergency medicineintensive carehepatology

Error types

system

Drugs involved

mersyndol daystrengthcodeine phosphateparacetamoltemazepamtramadoldiazepamacetylcysteine

Clinical conditions

paracetamol toxicityfulminant liver failureacute kidney injurycoagulopathylactic acidosiscerebral oedemasepsiscodeine dependencedepressionanxietysuicidal ideation

Procedures

intubationcentral line insertionbronchoscopycontinuous veno-venous haemofiltration

Contributing factors

  • Over-the-counter codeine combination analgesic (Mersyndol) dependence
  • Pharmacy shopping—purchasing from multiple pharmacies
  • Lack of real-time monitoring of OTC codeine sales across pharmacies
  • Inadequate pharmacist assessment of therapeutic need for repeated purchases
  • History of suicidal ideation and previous suicide attempts
  • Mental health conditions including depression, anxiety, and panic disorder

Coroner's recommendations

  1. A new cautionary and advisory label should be included in the Australian Pharmaceutical Formulary warning about toxicities associated with excessive doses of paracetamol, to be used whenever paracetamol/codeine combination products are supplied or dispensed
  2. Implementation of real-time monitoring of dispensing of OTC codeine products to detect pharmacy shopping and enable pharmacists to prevent over-supply and direct customers to appropriate clinicians for codeine dependence
Full text

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