Acute on chronic renal failure secondary to rhabdomyolysis as a consequence of drug interaction between Simvastatin and Clarithromycin
AI-generated summary
An 86-year-old man with chronic renal impairment (eGFR 37) died from acute-on-chronic renal failure secondary to rhabdomyolysis caused by a contraindicated drug interaction. His GP prescribed clarithromycin for a chest infection without ceasing simvastatin, despite this combination being explicitly contraindicated in MIMS since 2011. The GP's usual practice was to consult MIMS before prescribing, but he omitted this check because he had previously prescribed the same combination without incident (before the contraindication was formally documented). The coroner found the prescribing error causal in the death but accepted the GP's sincere acknowledgment of error and commitment to always consult prescribing references. Clinicians must verify current contraindications before every prescription, especially in patients with renal impairment, rather than relying on prior uneventful use. Drug interaction resources must be checked consistently regardless of previous patient history.
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Specialties
general practiceemergency medicinenephrologyforensic medicine
Lack of dose adjustment for clarithromycin in renal impairment
Reliance on prior uneventful use rather than current prescribing guidelines
Coroner's recommendations
Health professionals must check prescribing resources (such as MIMS) for every medication prescription to verify current contraindications, irrespective of the patient's prior medication history or the clinician's knowledge of the patient
GPs engaging in home visits should carry current hardcopy MIMS handbooks or use regularly updated mobile applications to ensure easy access to prescribing guidance
Special attention must be paid to drug interactions in patients with renal impairment, as dose adjustments and contraindications may apply
Systems must be established to alert prescribers to newly documented contraindications that may not have existed in previous versions of prescribing resources
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