Coronial
VIChospital

Finding into death of Eric Horace Julien

Deceased

Eric Horace Julien

Demographics

86y, male

Coroner

Coroner Audrey Jamieson

Date of death

2012-11-13

Finding date

2014-11-27

Cause of death

Acute on chronic renal failure secondary to rhabdomyolysis as a consequence of drug interaction between Simvastatin and Clarithromycin

AI-generated summary

An 86-year-old man with chronic renal impairment (eGFR 37) died from acute-on-chronic renal failure secondary to rhabdomyolysis caused by a contraindicated drug interaction. His GP prescribed clarithromycin for a chest infection without ceasing simvastatin, despite this combination being explicitly contraindicated in MIMS since 2011. The GP's usual practice was to consult MIMS before prescribing, but he omitted this check because he had previously prescribed the same combination without incident (before the contraindication was formally documented). The coroner found the prescribing error causal in the death but accepted the GP's sincere acknowledgment of error and commitment to always consult prescribing references. Clinicians must verify current contraindications before every prescription, especially in patients with renal impairment, rather than relying on prior uneventful use. Drug interaction resources must be checked consistently regardless of previous patient history.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

general practiceemergency medicinenephrologyforensic medicine

Error types

medicationdiagnostic

Drugs involved

simvastatinclarithromycinamoxicillin

Clinical conditions

rhabdomyolysisacute tubular necrosisacute-on-chronic renal failurechronic kidney diseasehypercholesterolaemiatype 2 diabeteshypertensioncoronary artery disease

Contributing factors

  • Prescribing of contraindicated drug combination (simvastatin and clarithromycin)
  • Failure to consult MIMS prescribing reference despite known contraindication
  • Pre-existing chronic renal failure (eGFR 37, creatinine 150 umol/L)
  • Lack of dose adjustment for clarithromycin in renal impairment
  • Reliance on prior uneventful use rather than current prescribing guidelines

Coroner's recommendations

  1. Health professionals must check prescribing resources (such as MIMS) for every medication prescription to verify current contraindications, irrespective of the patient's prior medication history or the clinician's knowledge of the patient
  2. GPs engaging in home visits should carry current hardcopy MIMS handbooks or use regularly updated mobile applications to ensure easy access to prescribing guidance
  3. Special attention must be paid to drug interactions in patients with renal impairment, as dose adjustments and contraindications may apply
  4. Systems must be established to alert prescribers to newly documented contraindications that may not have existed in previous versions of prescribing resources
Full text

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