A 65-year-old retired nurse died from paracetamol toxicity and liver failure after taking excessive paracetamol tablets for pain relief following a fractured arm. She presented to hospital on Saturday with a fracture. Critical pathology results showing markedly abnormal liver function (AST 2907) were faxed to the emergency department but not communicated by telephone despite exceeding the laboratory's own critical notification threshold by threefold. The emergency physician did not receive the abnormal results prior to patient transfer to the ward. Although the underlying ingestion could not have been prevented, earlier recognition of hepatotoxicity might have allowed earlier consideration of paracetamol overdose when the patient deteriorated. N-acetylcysteine administered after deterioration was too late, as it must be given within 24 hours of ingestion to prevent liver damage. Key lessons include: implementing robust pathology result communication protocols with mandatory telephone notification of critical values, ensuring results are reviewed before patient discharge/transfer, and maintaining detailed handover communication about abnormal findings between departments.
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paracetamol toxicityliver failurecentrilobular necrosishepatotoxicityfractured neck of humerusdiabetes mellitushyperglycemiacoronary artery atherosclerosishypotensioninfection/sepsisbipolar disorderalcohol abuse history
Contributing factors
Failure of Melbourne Pathology to telephone abnormal liver function results to treating physician despite exceeding laboratory's own critical notification threshold
Pathology results faxed to emergency department but not communicated verbally to treating emergency physician
Unknown person placed pathology report in medical file without bringing abnormal results to attention of clinician
Patient transferred to ward without emergency physician reviewing abnormal LFT results
Lack of robust handover and communication between departments regarding abnormal pathology results
Delayed recognition of paracetamol overdose due to lack of awareness of critical results
Patient ingested large quantity of paracetamol (approximately 100 Panadeine tablets) over several hours before hospital presentation
N-acetylcysteine administered only after liver damage already established (too late, as must be given within 24 hours of ingestion)
Complex medical presentation with multiple confounding issues (fracture, diabetes, alcohol history, infection) obscured the paracetamol overdose diagnosis
Coroner's recommendations
Epworth Hospital should implement robust pathology and radiology result follow-up protocols with allocated staff member responsible for signing off results daily
All abnormal results must have lowered thresholds for notification and treating doctors must be made aware before patient discharge
Pathology laboratories should have consistent procedures for immediate telephone notification of critical values in accordance with laboratory-specific critical intervals
Improved handover and communication processes between departments are essential to ensure abnormal findings are not lost during patient transfers
Electronic patient management systems should track whether abnormal results have been noted and actioned
Clinicians should understand the limitations of eGFR testing in unstable patients and not rely on these tests as reliable indicators of renal function in such circumstances
Early Medical Emergency Response Systems should be established in hospital inpatient environments to identify deteriorating patients earlier
Filing and notification processes for pathology results should be improved to prevent results being lost during patient transfers between departments
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