acute right heart failure (cor pulmonale) complicating foreign body (microcrystalline cellulose) granulomas of the lung caused by intravenous injection of crushed methylphenidate tablets
AI-generated summary
A 43-year-old male died from acute right heart failure (cor pulmonale) caused by pulmonary granulomas resulting from intravenous injection of crushed methylphenidate (Ritalin) tablets. The microcrystalline cellulose binder in pharmaceutical tablets is insoluble in blood and becomes lodged in lung vasculature, causing obstruction and inflammation. This case highlights the dangers of crushing oral medications and injecting them intravenously. Clinicians prescribing psychostimulants should conduct thorough risk assessment and monitoring. Public education campaigns addressing the hazards of intravenous drug injection and diversion of prescription stimulants are needed to prevent similar deaths.
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Specialties
forensic medicineaddiction medicinecardiothoracic surgery
Drugs involved
methylphenidatemethamphetaminecannabis
Clinical conditions
cor pulmonaleacute right heart failurepulmonary granulomaspulmonary vascular obstructionintravenous drug abuseopioid use disorder
Contributing factors
intravenous injection of crushed oral medication
microcrystalline cellulose binder in pharmaceutical tablets
pulmonary vascular obstruction
inflammatory reaction to foreign debris
history of intravenous drug abuse
lack of awareness of dangers of injecting oral medications
Coroner's recommendations
That relevant agencies consider whether there is a need for a public education campaign with a view to reducing the harm caused by illicit diversion of psychostimulants, and in particular, to highlight the dangerous practice of intravenous injection of such substances
That in developing updated guidelines for the issuing of authorities to prescribers, the PSB consider current evidence of the prevalence of and harm caused by diversion and misuse of psychostimulants in the community
That medical practitioners prescribing psychostimulant medication such as Ritalin continue to be vigilant in assessing the serious risks associated with such prescription and to ensure that careful assessment, planning, diagnosis, treatment and monitoring occurs in association with such prescribing
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