Coronial
SAhospital

Coroner's Finding: FIORETTI Louisa Jill Josephine

Deceased

Louisa Jill Josephine Fioretti

Demographics

19y, female

Date of death

2015-10-12

Finding date

2020-01-10

Cause of death

2,4-dinitrophenol toxicity

AI-generated summary

A 19-year-old woman died from 2,4-dinitrophenol (DNP) toxicity after intentionally ingesting approximately 50 x 250mg capsules purchased online. She presented to Flinders Medical Centre with an Inpatient Treatment Order in place. Despite expert multidisciplinary management including sedation, intubation, ECMO, attempted dialysis, charcoal administration, and dantrolene use, she deteriorated rapidly with uncontrollable hyperthermia and went into cardiac arrest. The coroner found treatment was expert and appropriate, but the dose was lethal and unsurvivable. DNP is a highly toxic uncontrolled substance with no antidote, resurgent popularity as an unregulated diet aid, and has since been prohibited for human use in Australia. Clinicians should be aware of DNP toxicity presentation and the lack of specific treatment.

AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.

Specialties

toxicologyemergency medicineintensive carepsychiatryanaesthesiacardiology

Drugs involved

2,4-dinitrophenoldantrolene

Clinical conditions

DNP toxicityhyperthermiametabolic derangementanxiety disorderdepressionintentional self-poisoning

Procedures

intubationextracorporeal membrane oxygenation (ECMO)dialysiscardiopulmonary resuscitation

Contributing factors

  • intentional overdose of lethal dose of DNP (approximately 50 x 250mg capsules)
  • uncontrollable hyperthermia despite cooling measures
  • DNP inhibits ATP production leading to rapid heat generation and increased metabolic rate
  • no specific antidote available
  • underlying mental health vulnerability including anxiety, depression, low self-worth and body image concerns
  • stressor events including romantic rejection and perceived social isolation
Full text

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