James Nicholson, aged 65, died from hypoxic ischaemic encephalopathy following a suicide attempt by hanging while an inpatient at Noarlunga Hospital on 18 August 2015. He had undergone extensive facial cancer surgery in January 2015, followed by chemotherapy and radiotherapy with concurrent dexamethasone from March 2015. Initial dexamethasone-induced hypomania progressed to psychosis, depression, and paranoid delusions as the dose was reduced. On 14 August, after concerning behaviour and suicidal statements at home, he was admitted to hospital where Emergency Department physician Dr H. correctly diagnosed steroid-induced psychosis and placed him on an Inpatient Treatment Order. However, psychiatrist Dr O. incorrectly revoked the order the next morning, diagnosing steroid withdrawal instead. The medical team then planned discharge without psychiatric review. Critical failures included: misdiagnosis of the underlying steroid-induced syndrome, failure to maintain the ITO, cessation of one-to-one nursing observation, non-implementation of recommended antipsychotic medication, and absence of proper psychiatric follow-up before discharge. Expert evidence confirmed the presentation was classical steroid-induced psychosis requiring continued medical management, antipsychotics, and close psychiatric monitoring.
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Specialties
oncologypsychiatryemergency medicineintensive care
cancer surgery with facial reconstructionchemotherapy administrationradiotherapyPEG tube insertion
Contributing factors
steroid-induced psychosis and depression incorrectly diagnosed as steroid withdrawal
revocation of Inpatient Treatment Order by psychiatrist despite psychotic presentation
cessation of one-to-one nursing observation
failure to initiate antipsychotic medication
absence of psychiatric review prior to planned discharge
miscommunication between medical and psychiatric teams regarding assessment plan
mismanagement of dexamethasone dosing (failure to implement recommended increase)
abrupt cessation of opioid analgesia contributing to mood disturbance
psychosocial stressor (theft of handbag triggering acute anxiety and paranoia)
Coroner's recommendations
The Minister for Health should publish a reminder to the medical profession of the need to be aware of the risk of steroid-induced psychosis in patients receiving corticosteroid medication
Medical professionals should be reminded that the possibility of symptoms being attributable to steroid withdrawal is much more remote than attributing symptoms to the introduction of the corticosteroid
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