Coronial
QLDhospital

Smith, David Frederick

Deceased

David Frederick Smith

Demographics

45y, male

Coroner

Ryan

Date of death

2019-07-22

Finding date

2023-01-24

Cause of death

Haemorrhagic transformation of cerebral infarction, due to bilateral internal carotid artery thrombosis (anticoagulated), due to essential thrombocythaemia

AI-generated summary

David Smith, aged 45, died from haemorrhagic transformation of cerebral infarction secondary to essential thrombocytosis with bilateral internal carotid artery thrombosis. He developed an acute ischaemic stroke on 9 July 2019 whilst in custody at Woodford Correctional Centre and was transferred to tertiary care. Despite appropriate anticoagulation with heparin at Royal Brisbane and Women's Hospital, he suffered catastrophic haemorrhagic transformation on 20 July 2019. The coroner found his medical care in custody and in hospital was appropriate. While there were gaps in cytoreductive medication (Anagrelide) administration due to both stock unavailability and patient refusal, expert evidence confirmed these gaps were unlikely to have contributed to his death. The case highlights the management challenges in anticoagulating patients with thrombocytosis who develop ischaemic stroke whilst on antiplatelet therapy.

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Specialties

haematologyneurologyvascular surgeryintensive careemergency medicinecorrectional health

Error types

system

Drugs involved

rivaroxabananagrelidehydroxycarbamideheparinaspirinpregabalinreboxetinemetoprololondansetronfentanyl

Clinical conditions

essential thrombocytosisacute ischaemic strokeinternal carotid artery thrombosishaemorrhagic transformation of infarctioncerebral infarction in left middle cerebral artery territoryatrial fibrillationthromboembolismintracranial haemorrhagetranstentorial herniationtonsillar herniation

Procedures

CT brain scanCT angiogramCT perfusion studyintubationheparin infusionorgan donation

Contributing factors

  • essential thrombocytosis with genetically-determined platelet overproduction
  • bilateral internal carotid artery thrombosis despite anticoagulation
  • gaps in administration of cytoreductive medication (Anagrelide) due to medication stock unavailability and patient refusal
  • medication non-compliance with prescribed cytoreductive agents
  • haemorrhagic transformation of ischaemic stroke as recognised complication of anticoagulation therapy
Full text

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