A 27-year-old veterinary nurse with a 5-year history of depression died from pentobarbitone toxicity self-administered at her workplace. She had two previous suicide attempts (2010, 2011) both involving alcohol. On the evening of her death, after receiving a phone call at a pub, her mood changed and she expressed suicidal ideation to her boyfriend, mentioning Lethabarb specifically. She consumed alcohol while taking duloxetine (Cymbalta), an SNRI with warnings against alcohol use due to risk of liver damage, dizziness and drowsiness. Her GP found no suicidal risk at her last consultation 2 weeks prior. Clinical lessons: alcohol significantly increased suicide risk in this patient with known depression and previous attempts; the GP-patient relationship lacked awareness of boyfriend concerns; workplace access to lethal agents despite being a known suicide risk was inadequately controlled; and the interaction between antidepressant medication and alcohol consumption required better patient education.
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