Overdose of quetiapine (Seroquel) in combination with alcohol
AI-generated summary
Travis Graham, a 31-year-old man with a history of mental illness, self-harm, and substance abuse, died from an overdose of quetiapine (Seroquel) combined with alcohol. He had previously overdosed on the same medication in 2006 and again in November 2007. A doctor prescribed Seroquel in November 2007 but recorded it as ceased due to 'nausea' following a serious overdose, without taking any steps to prevent further dispensing. The prescription remained active and was filled at two different pharmacies within three weeks before his death. Key clinical lessons include: doctors must actively cancel prescriptions through the Health Insurance Commission, not rely on patient destruction; pharmacies lack systems to detect duplicate prescriptions across locations; and high-risk medications require stricter dispensing controls and package size restrictions to prevent lethal accumulation.
AI-generated summary and tagging — may contain inaccuracies; refer to original finding for legal purposes. Report an inaccuracy.
Prescription for Seroquel recorded as ceased but not actively cancelled with Health Insurance Commission
No system in place to prevent duplicate prescriptions across multiple pharmacies
Prescriptions filled at two different locations within three weeks without pharmacist awareness
Doctor did not notify patient to return prescription or destroy repeats after cessation
Lack of communication between prescribing doctor and new general practitioner regarding active prescriptions
Large packet sizes (60 tablets per packet) allowing accumulation of lethal doses
Patient's history of suicide attempts and overdoses not adequately considered in prescribing decisions
Coroner's recommendations
The drug Seroquel be packaged, marketed and supplied in packets of 30 to protect against lethal doses of the medication being easily available to vulnerable members of society.
A national database containing dispensing histories for all patients be developed to enable pharmacists to identify over-dispensing of prescription medication, with facility to raise an alert if the same prescription medication has been dispensed by any pharmacist to the same patient within a short period of time.
Federal privacy laws be amended to enable PBS information about a patient to be disclosed to the approved supplier of medication to that patient.
Where concerns are raised with regard to authority prescriptions or such prescriptions are to be cancelled or withdrawn, that prescribing medical practitioners immediately advise the Health Insurance Commission, so that an alert can be raised on the Health Insurance Commission database which is available to all pharmacists in real time when dispensing medications.
A process be developed to ensure that prescriptions which have been cancelled or withdrawn by a treating medical practitioner are returned to the medical practitioner or destroyed, to prevent such prescriptions from being presented by patients to be dispensed.
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