multiple organ failure as a result of septic shock
AI-generated summary
Pauline Kessell, aged 53, died from septic shock caused by overwhelming sepsis following endoscopic pyeloscopy with laser lithotripsy for a 5cm infected staghorn calculus on 12 August 2015. Critical clinical lessons: (1) the surgeon should have recognised this as an infection stone requiring percutaneous nephrolithotomy rather than prolonged endoscopic manipulation, which created high intrarenal pressures leading to bacteraemia and endotoxin release; (2) no pre-operative antibiotic prophylaxis was documented despite positive urine culture; (3) the anaesthetist was not alerted to sepsis risk and could not leave theatre to review deteriorating patient; (4) nursing staff struggled to escalate concerns without specific criteria; (5) antibiotic administration in critical post-operative period was poorly coordinated with confusion over clinical responsibility. European and American guidelines recommend percutaneous nephrolithotomy for stones >2cm; the surgeon had not previously used endoscopy for stones >3cm.
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endoscopic pyeloscopy with laser lithotripsyintubationarterial line insertioncentral venous line insertion
Contributing factors
prolonged endoscopic pyeloscopy procedure (108 minutes active laser time) on large 5cm infected staghorn calculus
increased intrarenal pressure creating pyelovenous and pyelolymphatic backflow
dissemination of Proteus mirabilis bacteria and endotoxins into bloodstream
failure to use percutaneous nephrolithotomy for large stone despite international guidelines recommending it for stones >2cm
failure to alert anaesthetist to heightened sepsis risk
anaesthetist unable to leave operating theatre to review deteriorating post-operative patient
delayed clinical review of patient in PACU despite nursing concerns from 19:55 onwards
lack of clarity regarding responsibility for antibiotic administration
failure to administer ceftriaxone in PACU
delay in administering Tazocin (approximately 3 hours after ordering)
no intra-operative communication between surgeon and anaesthetist
Coroner's recommendations
To the Urological Association of Australia and New Zealand: give consideration to the need for further guidance to urologists on treatment of large staghorn calculi
To Ramsay Health Care and Westmead Private Hospital: incorporate in proposed Lessons Learned procedure consideration of problems arising where multiple consultants attend a patient regarding clarity of responsibility for ensuring antibiotic administration
To Ramsay Health Care and Westmead Private Hospital: incorporate in Lessons Learned procedure consideration of methods, including use of stat charts, for ensuring antibiotics are given promptly upon ordering
To Ramsay Health Care and Westmead Private Hospital: incorporate in Lessons Learned procedure consideration of and dissemination of information about the dilemma facing experienced PACU nurses in securing clinical review for concerning patients, addressing both those making calls (PACU nurses) and those receiving calls (anaesthetists/VMOs and Rapid Response Team members)
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