Coronial
NSWhospital

Inquest into the death of Pauline KESSELL

Deceased

Pauline Lynn Kessell

Demographics

53y, female

Coroner

Decision ofDeputy State Coroner Russell

Date of death

2015-08-14

Finding date

2019-08-07

Cause of death

multiple organ failure as a result of septic shock

AI-generated summary

Pauline Kessell, aged 53, died from septic shock caused by overwhelming sepsis following endoscopic pyeloscopy with laser lithotripsy for a 5cm infected staghorn calculus on 12 August 2015. Critical clinical lessons: (1) the surgeon should have recognised this as an infection stone requiring percutaneous nephrolithotomy rather than prolonged endoscopic manipulation, which created high intrarenal pressures leading to bacteraemia and endotoxin release; (2) no pre-operative antibiotic prophylaxis was documented despite positive urine culture; (3) the anaesthetist was not alerted to sepsis risk and could not leave theatre to review deteriorating patient; (4) nursing staff struggled to escalate concerns without specific criteria; (5) antibiotic administration in critical post-operative period was poorly coordinated with confusion over clinical responsibility. European and American guidelines recommend percutaneous nephrolithotomy for stones >2cm; the surgeon had not previously used endoscopy for stones >3cm.

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Specialties

urologyanaesthesiaintensive careinfectious diseases

Error types

diagnosticproceduralcommunicationsystemdelay

Drugs involved

gentamicintrimethoprimceftriaxonepiperacillin/tazobactampropofoloxycodonenoradrenalinealbumin

Clinical conditions

septic shockmultiple organ failureurosepsisstaghorn calculusinfection stoneproteus mirabilis bacteraemiasystemic inflammatory response syndrome

Procedures

endoscopic pyeloscopy with laser lithotripsyintubationarterial line insertioncentral venous line insertion

Contributing factors

  • prolonged endoscopic pyeloscopy procedure (108 minutes active laser time) on large 5cm infected staghorn calculus
  • increased intrarenal pressure creating pyelovenous and pyelolymphatic backflow
  • dissemination of Proteus mirabilis bacteria and endotoxins into bloodstream
  • failure to use percutaneous nephrolithotomy for large stone despite international guidelines recommending it for stones >2cm
  • failure to alert anaesthetist to heightened sepsis risk
  • anaesthetist unable to leave operating theatre to review deteriorating post-operative patient
  • delayed clinical review of patient in PACU despite nursing concerns from 19:55 onwards
  • lack of clarity regarding responsibility for antibiotic administration
  • failure to administer ceftriaxone in PACU
  • delay in administering Tazocin (approximately 3 hours after ordering)
  • no intra-operative communication between surgeon and anaesthetist

Coroner's recommendations

  1. To the Urological Association of Australia and New Zealand: give consideration to the need for further guidance to urologists on treatment of large staghorn calculi
  2. To Ramsay Health Care and Westmead Private Hospital: incorporate in proposed Lessons Learned procedure consideration of problems arising where multiple consultants attend a patient regarding clarity of responsibility for ensuring antibiotic administration
  3. To Ramsay Health Care and Westmead Private Hospital: incorporate in Lessons Learned procedure consideration of methods, including use of stat charts, for ensuring antibiotics are given promptly upon ordering
  4. To Ramsay Health Care and Westmead Private Hospital: incorporate in Lessons Learned procedure consideration of and dissemination of information about the dilemma facing experienced PACU nurses in securing clinical review for concerning patients, addressing both those making calls (PACU nurses) and those receiving calls (anaesthetists/VMOs and Rapid Response Team members)
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